Male pattern baldness study uncovers potential genetic predictors

The most common type of hair loss in men is male pattern baldness, study uncovers potential genetic predictors.

Symptoms of male pattern baldness:

The typical pattern of male baldness, start at the hairline. The hairline moves backward (recedes) and forms a shape “M”. Eventually the hair becomes shorter, finer and thinner then creates a U-shaped pattern of hair around the sides of the head.

What Causes:
Male pattern baldness is linked to your genes and male sex hormones. It follows a pattern of receding hairline and hair thinning on the crown. It can cause hormones and genetic predisposition.
Sits in a tiny hole (cavity) in the skin is called a follicle. Baldness is appeared when the hair follicle shrinks over time, developing in shorter and finer hair. When follicle does not grow new hair, they remain alive, which propose that is possible to grow new hair.
Male pattern baldness is appear in teenage years, but commonly is occurs in adult men.

Genetics study:
Large genome-wide association is study male pattern baldness.
Common variants involve in baldness is searched by researchers from the UK. It is based on genotype information for more than 52,000 UK Biobank participants. They were between the ages of 40 and 69 years old. They were found uncovered hundreds of variants on the autosomal chromosomes or X sex chromosome coinciding with male pattern baldness.

Genomic and experimental medicine researcher at the University of Edinburgh is Riccardo Marioni. He says that they are one step closer with those results.

Previous genetic studies suggest that some of the strongest genetic contributors to male pattern baldness fall on the X chromosome. Marioni and his co-authors note that the sex chromosome a man inherits from his mother.
Difficult is to understand its apparent ties to conditions such as prostate cancer and heart disease.
The team’s analysis found 247 autosomal variants and 40 X chromosome variants with apparent ties to baldness. Represent gene variants in men are thinning mops highlight 112 genes on autosomal chromosomes and more than a dozen X chromosome genes.

They repeat their analyses on a subset of 40,000 men. The researchers narrow in on potential polygenic risk scores for predicting slight, moderate, or severe hair loss in the other 12,874 study participants with between 64 percent and 74 percent sensitivity and 53 percent to 69 percent specificity. They note that the accuracy of such predictions got a bit of a boost by adding in individuals age.

In the study’s authors are noted that a substantial proportion of individual differences in hair loss patterns is explained by common genetic variants on the autosomes as well as on the X chromosome. X chromosome variant is much lower for late onset correlate to early-onset male pattern baldness.

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